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Important Safety Information for KYZATREX (testosterone undecanoate)

KYZATREX® (testosterone undecanoate) is a prescription drug that is used to treat adult men who have low or no testosterone levels due to certain medical conditions. KYZATREX® is a controlled substance (CIII) because it contains testosterone. It is not known if KYZATREX® is safe or effective in males younger than 18 years old. Improper use may affect bone growth in children.

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Oral Testosterone Replacement Therapy
No Needles. No Gels.
Just Two Doses a Day.
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KYZATREX® (testosterone undecanoate) is a prescription oral testosterone treatment for adult men who have low or no testosterone levels due to certain medical conditions.
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Frame (1)No Gels
Frame (2)Shipped to your door
KYZATREX is a controlled substance (CIII) because it contains testosterone.
It is not known if KYZATREX is safe or effective in males younger than 18 years old.
Improper use may affect bone growth in children. It is not known if KYZATREX is safe or effective in men with “age-related hypogonadism” (also referred to as “late-onset hypogonadism”).
KYZATREX is not meant for use by women.
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From Intake To Treatment In Days — Not Weeks

Your Plan Starts Here

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Container  Complete Your Intake
Answer a few questions about your symptoms and health history online — takes minutes.
Container (1)  Get Your Lab Work
Lab work is required and included. Complete it at a walk-in location near you or with an at-home kit.
Container (2)  Provider Review
A licensed clinician reviews your labs and intake to determine if KYZATREX is appropriate for you.
Container (3)  KYZATREX Delivered
If prescribed, your medication ships directly to your door. Discreet packaging. Fast turnaround.
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This telehealth service is independent of Marius Pharmaceuticals and does not constitute a recommendation or referral for any specific product.
Feel Like Something’s Off?
Low T May Be the Culprit
More than 1 in 3 men over 45 may have reduced testosterone levels.1
If you experience any of the following symptoms, consider checking your testosterone levels.
Broken Heart 1Low Sex Drive
People Burnout 1Fatigue / Low Energy
Duration Jet Lag 1Difficulty Sleeping
Strenght 1Reduced Muscle Mass
Medical 2Decreased Bone Density
Body Scale with Weights 1Weight Gain
Bipolar Disorder 1Mood Changes
Focus 1Difficulty Concentrating
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dr-jared

Medical Leadership

Dr. Jared Pelo

Dr. Jared Pelo has spent years caring for men with low testosterone and has prescribed KYZATREX for the past three years since its launch, giving him deep, hands-on experience with how patients respond to oral testosterone therapy. An emergency medicine physician and health-tech founder, he also built one of the leading AI tools in healthcare, now owned by Microsoft, and currently oversees the Get KYZATREX program.

Not Just A Prescription

A Physician-Supervised Treatment Plan

KYZATREX isn't a one-and-done script. Getting KYZATREX through this program means a licensed provider reviews your labs, confirms the diagnosis, and monitors your treatment from intake to treatment.

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RESULTS YOU CAN TRACK
Powered by Your Labs
Your provider reviews Total Testosterone, Free Testosterone, SHBG, estradiol, PSA, and CBC, then builds an individualized plan for you, with ongoing tracking of your biomarkers to monitor progress and optimize treatment over time.
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SIMPLE. STRAIGHTFORWARD. IN CONTROL.
Oral TRT Made Easy
Two daily doses with food.
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Effective Results with Oral TRT
KYZATREX is clinically proven to restore testosterone to normal levels.2 FDA-approved, liver-safe, and backed by an open-label, single-arm, multi-center trial in 139 hypogonadal men.2
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96percent
Up to 96% effective in clinical trials2*
Clinically proven to restore T to normal physiological range
2times
Increase in mean free testosterone2
More bioavailable testosterone where your body needs it
30percent
30% Decrease in mean SHBG levels3
SHBG can lock up testosterone, making it unavailable to your cells. Decreasing SHBG frees up more testosterone to do its job.4
*In a six-month clinical trial of 139 men with low testosterone, 88% of patients had normal testosterone levels at Day 90 (Cavg, 222-800 ng/dL) (worst case scenario calculation, excluding Investigator Site 104). Based on patients who completed the study (n=127), 96% of patients achieved normal testosterone levels at Day 90.
FDA-Approved Oral Testosterone
No Needles. No Gels. No Waiting.
Just two daily doses with food. See if KYZATREX fits into your life — no clinic visits for procedures, no mess, no pain.
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The Next Phase in Testosterone Treatment
How KYZATREX Works
The active ingredient in KYZATREX, testosterone undecanoate, is absorbed through the lymphatic system, not the liver. That means it enters your bloodstream efficiently and avoids liver toxicity linked to oral methyltestosterone.
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Easy to Take
Two daily doses, with food. No injections, no gels, no patches.
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Flexible Dosing
Multiple dose strengths available, customized to your individual needs by your licensed provider.
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Bypasses the Liver
KYZATREX is absorbed through the lymphatic system and bypasses the liver. By bypassing the liver altogether, KYZATREX helps avoid the liver toxicity often associated with previous generations of oral testosterone.2
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Everything Included. Nothing Hidden.
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IconOnline physician consultation
IconRequired lab work (included)
IconKYZATREX medication
IconNo insurance needed
IconNo long-term commitment
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Why KYZATREX
IconOral capsule — no needles or gels
IconSimple twice-daily routine
Have Questions?
Talk with a provider about your labs, medical history, and whether KYZATREX is right for you.
LET'S CHAT
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Still Have Questions?
We've Got Answers.
Whether you're curious about cost, how the medication works, or what to expect, find what you need here.
What is KYZATREX?

KYZATREX is an FDA-approved oral testosterone for men who have low or no testosterone levels due to certain medical conditions.
KYZATREX is a controlled substance (CIII) because it contains testosterone. It is not known if KYZATREX is safe or effective in males younger than 18 years old. Improper use may affect bone growth in children. KYZATREX is not meant for use by women.
Learn more about KYZATREX.

Who can take KYZATREX?

KYZATREX is used to treat men who have low or no testosterone due to certain medical conditions. It is not known if KYZATREX is safe or effective in children younger than 18 years old. Improper use of KYZATREX may affect bone growth in children.
Do not take KYZATREX if you: have breast cancer; have or might have prostate cancer; are a woman who is pregnant (KYZATREX may harm your unborn baby); are allergic to KYZATREX or any of its ingredients.

How do I take KYZATREX?

KYZATREX is taken orally, with two doses a day alongside food. Your healthcare provider will provide specific instructions based on your treatment plan.

Is KYZATREX bad for my liver?

No. KYZATREX was specifically designed to be absorbed lymphatically. This means it bypasses your liver altogether, helping to avoid the liver toxicity often associated with previous generations of oral testosterone.1

How does KYZATREX work?
KYZATREX is an immediate-release oral testosterone undecanoate. It is absorbed through the lymphatic system, where the body then uses it to replace testosterone that has been lost as a result of various medical conditions.
How is low testosterone diagnosed?

Diagnosing Low T involves simple lab tests to measure your Total Testosterone (Total T) and Free Testosterone (Free T), along with Sex Hormone Binding Globulin (SHBG), which affects Free T availability. Total T gives an overall level, while Free T shows the testosterone available for your body’s use. High SHBG can lower Free T, impacting its availability. Your doctor may suggest these tests and follow-up labs to monitor your testosterone levels over time, ensuring your treatment is accurately tailored to your needs.

Is KYZATREX safe?

KYZATREX is a controlled substance (CIII) because it contains testosterone. It is not known if KYZATREX is safe or effective in males younger than 18 years old. Improper use may affect bone growth in children. KYZATREX is not meant for use by women.
In the phase 3 clinical trial for KYZATREX (n=155), 4 patients (2.6%) reported high blood pressure. A total of 5 patients (3.2%) began taking new antihypertensive medications after study start. No patient increased their dose of antihypertensive medication.
Your healthcare provider will monitor your blood pressure while you are being treated with KYZATREX. If your blood pressure increases, you may need to start medication to control your blood pressure. If you are currently taking blood pressure medicines, they may need to be changed or new blood pressure medicines may need to be added. If your blood pressure cannot be controlled, KYZATREX may need to be stopped.
See additional Important Safety Information for KYZATREX below.

References:
1. Li Y, Liu M, Cui Y, et al. Increased risk of testosterone deficiency is associated with the systemic immune-inflammation index: a population-based cohort study. Front Endocrinol. 2022;13:975773. doi:10.3389/fendo.2022.974773
2. Bernstein JS, Dhingra OP. A phase III, single-arm, 6-month trial of a wide-dose range oral testosterone undecanoate product. Ther Adv Urol. 2024;16. doi:10.1177/17562872241241864 
3. Data on file. Raleigh, NC: Marius Pharmaceuticals, 2020. 
4. Krakowsky Y, Grober E. Testosterone deficiency – Establishing a Biochemical Diagnosis. EJIFCC. 2015 Mar; 26(2): 105–113.PMID: 27683486; PMCID: PMC4975356.